2-(2-Cholesteroxyethoxyl)ethyl 3'-S-glutathionylpropionate and its self-assembled micelles for brain delivery: Design, synthesis and evaluation
Water, 1,2-Hexanediol, Hydrogenated Lecithin, Glutathione, Disodium EDTA, Ceramide NP, Methylpropanediol, Glycerin, Niacinamide, Butylene Glycol, Sodium Ascorbyl Phosphate, Pyridoxine, Riboflavin, Biotin, Cyanocobalamin, Ascorbic Acid, Thiamine HCl, Folic Acid, Propanediol, Glycereth-26, Dipropylene Glycol, Sodium Hyaluronate, Polyglycerin-3, Glyceryl Acrylate/Acrylic Acid Copolymer, PVM/MA Copolymer, Carbomer, Arginine, Allantoin, Polyglyceryl-10 Laurate, Coptis Japonica Root Extract, Ethylhexylglycerin, Xanthan Gum, Panthenol, Hippophae Rhamnoides Water, Methyl Diisopropyl Propionamide, Fragrance, Sodium Polyacrylate, Acetyl Glucosamine, 3-O-Ethyl Ascorbic Acid, Lecithin, Polysorbate 20, Retinol, Tocopherol
4H) was created by authors (K.B.C, and D.Y.K) with BioRender.com
Cell Calcium 90 , 102242 (2020)
However, GCL is upregulated by estradiol, leading to a higher concentration of glutamyl-cysteine (Glut-Cys) in females, thereby driving increased GS flux
Women of childbearing age should use contraception while on tirzepatide and discontinue the medication at least 2 months before attempting conception to allow complete washout given the long half-life